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Christian Lefebvre d’Hellencourt has received his PhD degree from the University of Paris 7, France in 1995. He has been assistant professor at the University of Angers, France from 1996 to 1998. Then from 1999 to 2003, Christian Lefebvre d’Hellencourt performed a postdoctoral training with Jean Harry, in the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Durham, North Carolina, USA. In 2003, the University of La Réunion, France hired him as assistant professor and habilitation was achieved in 2004. He has been director of the laboratory of Biochemistry and Molecular Genetics (EA2526) in the University of La Réunion from 2005 to 2010. Since 2010, he is the director of EA 4516 (Study Group on Chronic Inflammation and Obesity, GEICO) at University of La Réunion. In 2011, he became full Professor. Christian Lefebvre d’Hellencourt is member of the scientific board and Medicine faculty board of University of La Réunion, research board of the Réunion University hospital (CRBSP) and member of the French National University Board for Biochemistry and Molecular Biology (CNU 64). His research interests reside on inflammation modulation in pathologies, with a main focus on obesity effects on vulnerability of the central nervous system. Effects of peripheral inflammation and factors produced by adipose tissue on neuroinflammation and changed in trauma susceptibility in the central nervous system are some of the recent researches conducted in his laboratory. Glial cells (astrocytes and microglia) are especially studied in different model of neuroinflammation and neurodegeneration, both in vitro (cell cultures) and in vivo in mice. He has successfully supervised 3 PhD students and 9 master thesis.
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PUBLICATIONS
Diabetes, adult neurogenesis and brain remodeling: New insights from rodent and zebrafish models.
Dorsemans AC, Couret D, Hoarau A, Meilhac O, Lefebvre d'Hellencourt C, Diotel N.Neurogenesis (Austin). 2017 Jan 31;4(1):e1281862. doi: 10.1080/23262133.2017.1281862. eCollection 2017.PMID: 28439518 Free PMC article. Review.
Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research.
Parimisetty A, Dorsemans AC, Awada R, Ravanan P, Diotel N, Lefebvre d'Hellencourt C.J Neuroinflammation. 2016 Mar 24;13(1):67. doi: 10.1186/s12974-016-0530-x.PMID: 27012931 Free PMC article. Review.
Curcumin-Encapsulated Nanomicelles Promote Tissue Regeneration in Zebrafish Eleutheroembryo.
Narra SS, Gence L, Youssouf L, Couprie J, Giraud P, Diotel N, Lefebvre D'Hellencourt C.Zebrafish. 2023 Oct;20(5):200-209. doi: 10.1089/zeb.2023.0007. Epub 2023 Aug 29.PMID: 37643300
High Content Imaging and Quantification of Microglia Phagocytosis In Vitro.
McPherson CA, Kelly-Rajan K, Lefebvre d'Hellencourt C, Harry GJ.Curr Protoc. 2023 Jan;3(1):e638. doi: 10.1002/cpz1.638.PMID: 36622815 Free PMC article.
Deleterious Effects of Overfeeding on Brain Homeostasis and Plasticity in Adult Zebrafish.
Ghaddar B, Bringart M, Lefebvre d'Hellencourt C, Meilhac O, Diotel N.Zebrafish. 2021 Jun;18(3):190-206. doi: 10.1089/zeb.2020.1962. Epub 2021 May 21.PMID: 34028307
Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish.
Dorsemans AC, Soulé S, Weger M, Bourdon E, Lefebvre d'Hellencourt C, Meilhac O, Diotel N.J Comp Neurol. 2017 Feb 15;525(3):442-458. doi: 10.1002/cne.24065. Epub 2016 Jul 4.PMID: 27339277
Metabolic disorders exacerbate the formation of glial scar after stroke.
Clain J, Couret D, Bringart M, Lecadieu A, Meilhac O, Lefebvre d'Hellencourt C, Diotel N.Eur J Neurosci. 2024 Jun;59(11):3009-3029. doi: 10.1111/ejn.16325. Epub 2024 Apr 4.PMID: 38576159
Distribution of Adiponectin Receptors in the Brain of Adult Mouse: Effect of a Single Dose of the Adiponectin Receptor Agonist, AdipoRON, on Ischemic Stroke.
Clain J, Couret D, Planesse C, Krejbich-Trotot P, Meilhac O, Lefebvre d'Hellencourt C, Viranaicken W, Diotel N.Brain Sci. 2022 May 23;12(5):680. doi: 10.3390/brainsci12050680.PMID: 35625066 Free PMC article.
The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression.
El Safadi D, Lebeau G, Turpin J, Lefebvre d'Hellencourt C, Diotel N, Viranaicken W, Krejbich-Trotot P.Viruses. 2023 Dec 22;16(1):24. doi: 10.3390/v16010024.PMID: 38257725 Free PMC article.
Distribution of microglia/immune cells in the brain of adult zebrafish in homeostatic and regenerative conditions: Focus on oxidative stress during brain repair.
Narra SS, Rondeau P, Fernezelian D, Gence L, Ghaddar B, Bourdon E, Lefebvre d'Hellencourt C, Rastegar S, Diotel N.J Comp Neurol. 2023 Feb;531(2):238-255. doi: 10.1002/cne.25421. Epub 2022 Oct 25.PMID: 36282721
Impaired brain homeostasis and neurogenesis in diet-induced overweight zebrafish: a preventive role from A. borbonica extract.
Ghaddar B, Veeren B, Rondeau P, Bringart M, Lefebvre d'Hellencourt C, Meilhac O, Bascands JL, Diotel N.Sci Rep. 2020 Sep 2;10(1):14496. doi: 10.1038/s41598-020-71402-2.PMID: 32879342 Free PMC article.
Finally, we investigated the preventive beneficial effects of A. borbonica, an endogenous plant from Reunion Island. Overnight treatment with A. borbonica aqueous extract during the 4 weeks of overfeeding limited some detrimental central effects of DIO. ...
Enhanced effects of curcumin encapsulated in polycaprolactone-grafted oligocarrageenan nanomicelles, a novel nanoparticle drug delivery system.
Youssouf L, Bhaw-Luximon A, Diotel N, Catan A, Giraud P, Gimié F, Koshel D, Casale S, Bénard S, Meneyrol V, Lallemand L, Meilhac O, Lefebvre D'Hellencourt C, Jhurry D, Couprie J.Carbohydr Polym. 2019 Aug 1;217:35-45. doi: 10.1016/j.carbpol.2019.04.014. Epub 2019 Apr 5.PMID: 31079683
Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules.
Dorsemans AC, Lefebvre d'Hellencourt C, Ait-Arsa I, Jestin E, Meilhac O, Diotel N.J Vis Exp. 2017 Jun 26;(124):55203. doi: 10.3791/55203.PMID: 28671660 Free PMC article.
Expression of adiponectin receptors in the brain of adult zebrafish and mouse: Links with neurogenic niches and brain repair.
Rastegar S, Parimisetty A, Cassam Sulliman N, Narra SS, Weber S, Rastegar M, Viranaicken W, Couret D, Planesse C, Strähle U, Meilhac O, Lefebvre d'Hellencourt C, Diotel N.J Comp Neurol. 2019 Oct 1;527(14):2317-2333. doi: 10.1002/cne.24669. Epub 2019 Mar 29.PMID: 30843204
Dorsemans AC, Couret D, Hoarau A, Meilhac O, Lefebvre d'Hellencourt C, Diotel N.Neurogenesis (Austin). 2017 Jan 31;4(1):e1281862. doi: 10.1080/23262133.2017.1281862. eCollection 2017.PMID: 28439518 Free PMC article. Review.
Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research.
Parimisetty A, Dorsemans AC, Awada R, Ravanan P, Diotel N, Lefebvre d'Hellencourt C.J Neuroinflammation. 2016 Mar 24;13(1):67. doi: 10.1186/s12974-016-0530-x.PMID: 27012931 Free PMC article. Review.
Curcumin-Encapsulated Nanomicelles Promote Tissue Regeneration in Zebrafish Eleutheroembryo.
Narra SS, Gence L, Youssouf L, Couprie J, Giraud P, Diotel N, Lefebvre D'Hellencourt C.Zebrafish. 2023 Oct;20(5):200-209. doi: 10.1089/zeb.2023.0007. Epub 2023 Aug 29.PMID: 37643300
High Content Imaging and Quantification of Microglia Phagocytosis In Vitro.
McPherson CA, Kelly-Rajan K, Lefebvre d'Hellencourt C, Harry GJ.Curr Protoc. 2023 Jan;3(1):e638. doi: 10.1002/cpz1.638.PMID: 36622815 Free PMC article.
Deleterious Effects of Overfeeding on Brain Homeostasis and Plasticity in Adult Zebrafish.
Ghaddar B, Bringart M, Lefebvre d'Hellencourt C, Meilhac O, Diotel N.Zebrafish. 2021 Jun;18(3):190-206. doi: 10.1089/zeb.2020.1962. Epub 2021 May 21.PMID: 34028307
Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish.
Dorsemans AC, Soulé S, Weger M, Bourdon E, Lefebvre d'Hellencourt C, Meilhac O, Diotel N.J Comp Neurol. 2017 Feb 15;525(3):442-458. doi: 10.1002/cne.24065. Epub 2016 Jul 4.PMID: 27339277
Metabolic disorders exacerbate the formation of glial scar after stroke.
Clain J, Couret D, Bringart M, Lecadieu A, Meilhac O, Lefebvre d'Hellencourt C, Diotel N.Eur J Neurosci. 2024 Jun;59(11):3009-3029. doi: 10.1111/ejn.16325. Epub 2024 Apr 4.PMID: 38576159
Distribution of Adiponectin Receptors in the Brain of Adult Mouse: Effect of a Single Dose of the Adiponectin Receptor Agonist, AdipoRON, on Ischemic Stroke.
Clain J, Couret D, Planesse C, Krejbich-Trotot P, Meilhac O, Lefebvre d'Hellencourt C, Viranaicken W, Diotel N.Brain Sci. 2022 May 23;12(5):680. doi: 10.3390/brainsci12050680.PMID: 35625066 Free PMC article.
The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression.
El Safadi D, Lebeau G, Turpin J, Lefebvre d'Hellencourt C, Diotel N, Viranaicken W, Krejbich-Trotot P.Viruses. 2023 Dec 22;16(1):24. doi: 10.3390/v16010024.PMID: 38257725 Free PMC article.
Distribution of microglia/immune cells in the brain of adult zebrafish in homeostatic and regenerative conditions: Focus on oxidative stress during brain repair.
Narra SS, Rondeau P, Fernezelian D, Gence L, Ghaddar B, Bourdon E, Lefebvre d'Hellencourt C, Rastegar S, Diotel N.J Comp Neurol. 2023 Feb;531(2):238-255. doi: 10.1002/cne.25421. Epub 2022 Oct 25.PMID: 36282721
Impaired brain homeostasis and neurogenesis in diet-induced overweight zebrafish: a preventive role from A. borbonica extract.
Ghaddar B, Veeren B, Rondeau P, Bringart M, Lefebvre d'Hellencourt C, Meilhac O, Bascands JL, Diotel N.Sci Rep. 2020 Sep 2;10(1):14496. doi: 10.1038/s41598-020-71402-2.PMID: 32879342 Free PMC article.
Finally, we investigated the preventive beneficial effects of A. borbonica, an endogenous plant from Reunion Island. Overnight treatment with A. borbonica aqueous extract during the 4 weeks of overfeeding limited some detrimental central effects of DIO. ...
Enhanced effects of curcumin encapsulated in polycaprolactone-grafted oligocarrageenan nanomicelles, a novel nanoparticle drug delivery system.
Youssouf L, Bhaw-Luximon A, Diotel N, Catan A, Giraud P, Gimié F, Koshel D, Casale S, Bénard S, Meneyrol V, Lallemand L, Meilhac O, Lefebvre D'Hellencourt C, Jhurry D, Couprie J.Carbohydr Polym. 2019 Aug 1;217:35-45. doi: 10.1016/j.carbpol.2019.04.014. Epub 2019 Apr 5.PMID: 31079683
Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules.
Dorsemans AC, Lefebvre d'Hellencourt C, Ait-Arsa I, Jestin E, Meilhac O, Diotel N.J Vis Exp. 2017 Jun 26;(124):55203. doi: 10.3791/55203.PMID: 28671660 Free PMC article.
Expression of adiponectin receptors in the brain of adult zebrafish and mouse: Links with neurogenic niches and brain repair.
Rastegar S, Parimisetty A, Cassam Sulliman N, Narra SS, Weber S, Rastegar M, Viranaicken W, Couret D, Planesse C, Strähle U, Meilhac O, Lefebvre d'Hellencourt C, Diotel N.J Comp Neurol. 2019 Oct 1;527(14):2317-2333. doi: 10.1002/cne.24669. Epub 2019 Mar 29.PMID: 30843204