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Christine Robert-Da Silva received her PhD degree in Biochemistry in 1996 from University of La Réunion, France. Her work consisted in the study of Polyphenoloxidase, the enzyme responsible for the browning of Acanthophoenix rubra, an endemic palmito from Mascareignas. Since 1998, she is an assistant professor in the same university. Since 2011, Christine Robert-Da Silva is the Head of the Biochemistry and Molecular Biology Teaching Department. She is also the academic supervisor of the students preparing the Bachelor of Science in Biochemistry. As a member of GEICO, her work aims to understand the inflammatory response of adipose tissue during obesity and diabetes and to evaluate the antioxidant and anti inflammatory properties of polyphenol-rich plant extracts as new nutritional and phytopharmacological strategies which could help to reduce obesity-related disorders. This work is mainly based on the contribution of PhD and Master degree students.
RESEARCH GATE LINK Scientific summaryPCR
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Selected PUBLICATIONS
Cell cycle and mitosis progression during ZIKA virus infection: The viral non-structural protein NS5 as a master regulator of the APC/cyclosome?
Lebeau G, Hoareau M, Rivière S, El Safadi D, Da Silva CR, Krejbich-Trotot P, Viranaicken W.Biochimie. 2024 Jun;221:75-80. doi: 10.1016/j.biochi.2024.01.016. Epub 2024 Feb 1.PMID: 38307244
Fermented Pineapple Juice Consumption Limits Metabolic Disorders Associated to Sugary Drinks on High-Fat Diet-Fed Mice.
Guérin M, Remize F, Bringart M, Planesse C, Rondeau P, Robert-Da Silva C, Garcia C.Mol Nutr Food Res. 2023 Jun;67(11):e2200670. doi: 10.1002/mnfr.202200670. Epub 2023 May 19.PMID: 36949666
Protective Effects of Medicinal Plant Decoctions on Macrophages in the Context of Atherosclerosis.
Checkouri E, Ramin-Mangata S, Diotel N, Viranaicken W, Marodon C, Reignier F, Robert-Da Silva C, Meilhac O.Nutrients. 2021 Jan 19;13(1):280. doi: 10.3390/nu13010280.PMID: 33478034 Free PMC article.
Evaluation of Polyphenol Content and Antioxidant Capacity of Aqueous Extracts from Eight Medicinal Plants from Reunion Island: Protection against Oxidative Stress in Red Blood Cells and Preadipocytes.
Checkouri E, Reignier F, Robert-Da Silva C, Meilhac O.Antioxidants (Basel). 2020 Oct 7;9(10):959. doi: 10.3390/antiox9100959.PMID: 33036442 Free PMC article.
Porphyromonas gingivalis lipopolysaccharides act exclusively through TLR4 with a resilience between mouse and human.
Nativel B, Couret D, Giraud P, Meilhac O, d'Hellencourt CL, Viranaïcken W, Da Silva CR.Sci Rep. 2017 Nov 17;7(1):15789. doi: 10.1038/s41598-017-16190-y.PMID: 29150625 Free PMC article.
Recombinant human HSP60 produced in ClearColi™ BL21(DE3) does not activate the NFκB pathway.
Planesse C, Nativel B, Iwema T, Gasque P, Robert-Da Silva C, Viranaïcken W.Cytokine. 2015 May;73(1):190-5. doi: 10.1016/j.cyto.2015.01.028. Epub 2015 Mar 12.PMID: 25771243
Antioxidant polyphenol-rich extracts from the medicinal plants Antirhea borbonica, Doratoxylon apetalum and Gouania mauritiana protect 3T3-L1 preadipocytes against H2O2, TNFα and LPS inflammatory mediators by regulating the expression of superoxide dismutase and NF-κB genes.
Marimoutou M, Le Sage F, Smadja J, Lefebvre d'Hellencourt C, Gonthier MP, Robert-Da Silva C.J Inflamm (Lond). 2015 Feb 8;12:10. doi: 10.1186/s12950-015-0055-6. eCollection 2015.PMID: 25685071 Free PMC article.
Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line: contribution to chronic inflammation in fat tissue.
Nativel B, Marimoutou M, Thon-Hon VG, Gunasekaran MK, Andries J, Stanislas G, Planesse C, Da Silva CR, Césari M, Iwema T, Gasque P, Viranaicken W.PLoS One. 2013 Sep 20;8(9):e76039. doi: 10.1371/journal.pone.0076039. eCollection 2013.PMID: 24073286 Free PMC article.
Citrus fruit extracts reduce advanced glycation end products (AGEs)- and H₂O₂-induced oxidative stress in human adipocytes.
Ramful D, Tarnus E, Rondeau P, Da Silva CR, Bahorun T, Bourdon E.J Agric Food Chem. 2010 Oct 27;58(20):11119-29. doi: 10.1021/jf102762s. Epub 2010 Sep 30.PMID: 20882960
Identification of endocannabinoids and related compounds in human fat cells.
Gonthier MP, Hoareau L, Festy F, Matias I, Valenti M, Bès-Houtmann S, Rouch C, Robert-Da Silva C, Chesne S, Lefebvre d'Hellencourt C, Césari M, Di Marzo V, Roche R.Obesity (Silver Spring). 2007 Apr;15(4):837-45. doi: 10.1038/oby.2007.581.PMID: 17426318 Free article.
Lebeau G, Hoareau M, Rivière S, El Safadi D, Da Silva CR, Krejbich-Trotot P, Viranaicken W.Biochimie. 2024 Jun;221:75-80. doi: 10.1016/j.biochi.2024.01.016. Epub 2024 Feb 1.PMID: 38307244
Fermented Pineapple Juice Consumption Limits Metabolic Disorders Associated to Sugary Drinks on High-Fat Diet-Fed Mice.
Guérin M, Remize F, Bringart M, Planesse C, Rondeau P, Robert-Da Silva C, Garcia C.Mol Nutr Food Res. 2023 Jun;67(11):e2200670. doi: 10.1002/mnfr.202200670. Epub 2023 May 19.PMID: 36949666
Protective Effects of Medicinal Plant Decoctions on Macrophages in the Context of Atherosclerosis.
Checkouri E, Ramin-Mangata S, Diotel N, Viranaicken W, Marodon C, Reignier F, Robert-Da Silva C, Meilhac O.Nutrients. 2021 Jan 19;13(1):280. doi: 10.3390/nu13010280.PMID: 33478034 Free PMC article.
Evaluation of Polyphenol Content and Antioxidant Capacity of Aqueous Extracts from Eight Medicinal Plants from Reunion Island: Protection against Oxidative Stress in Red Blood Cells and Preadipocytes.
Checkouri E, Reignier F, Robert-Da Silva C, Meilhac O.Antioxidants (Basel). 2020 Oct 7;9(10):959. doi: 10.3390/antiox9100959.PMID: 33036442 Free PMC article.
Porphyromonas gingivalis lipopolysaccharides act exclusively through TLR4 with a resilience between mouse and human.
Nativel B, Couret D, Giraud P, Meilhac O, d'Hellencourt CL, Viranaïcken W, Da Silva CR.Sci Rep. 2017 Nov 17;7(1):15789. doi: 10.1038/s41598-017-16190-y.PMID: 29150625 Free PMC article.
Recombinant human HSP60 produced in ClearColi™ BL21(DE3) does not activate the NFκB pathway.
Planesse C, Nativel B, Iwema T, Gasque P, Robert-Da Silva C, Viranaïcken W.Cytokine. 2015 May;73(1):190-5. doi: 10.1016/j.cyto.2015.01.028. Epub 2015 Mar 12.PMID: 25771243
Antioxidant polyphenol-rich extracts from the medicinal plants Antirhea borbonica, Doratoxylon apetalum and Gouania mauritiana protect 3T3-L1 preadipocytes against H2O2, TNFα and LPS inflammatory mediators by regulating the expression of superoxide dismutase and NF-κB genes.
Marimoutou M, Le Sage F, Smadja J, Lefebvre d'Hellencourt C, Gonthier MP, Robert-Da Silva C.J Inflamm (Lond). 2015 Feb 8;12:10. doi: 10.1186/s12950-015-0055-6. eCollection 2015.PMID: 25685071 Free PMC article.
Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line: contribution to chronic inflammation in fat tissue.
Nativel B, Marimoutou M, Thon-Hon VG, Gunasekaran MK, Andries J, Stanislas G, Planesse C, Da Silva CR, Césari M, Iwema T, Gasque P, Viranaicken W.PLoS One. 2013 Sep 20;8(9):e76039. doi: 10.1371/journal.pone.0076039. eCollection 2013.PMID: 24073286 Free PMC article.
Citrus fruit extracts reduce advanced glycation end products (AGEs)- and H₂O₂-induced oxidative stress in human adipocytes.
Ramful D, Tarnus E, Rondeau P, Da Silva CR, Bahorun T, Bourdon E.J Agric Food Chem. 2010 Oct 27;58(20):11119-29. doi: 10.1021/jf102762s. Epub 2010 Sep 30.PMID: 20882960
Identification of endocannabinoids and related compounds in human fat cells.
Gonthier MP, Hoareau L, Festy F, Matias I, Valenti M, Bès-Houtmann S, Rouch C, Robert-Da Silva C, Chesne S, Lefebvre d'Hellencourt C, Césari M, Di Marzo V, Roche R.Obesity (Silver Spring). 2007 Apr;15(4):837-45. doi: 10.1038/oby.2007.581.PMID: 17426318 Free article.