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Originally from Marseille, Professor COURET completed his entire medical training there before arriving in La Réunion in 2011. Appointed as a hospital practitioner the following year in neuro-reanimation, he has since worked in the same department. At the same time, he is studying science at the University of La Réunion (Masters in Molecular Biology). As an extension of this course, he is starting a science thesis on cerebral ischaemia and neuroprotection.
Professor COURET is currently continuing his research into cerebral ischaemia within the DeTROI unit, where he is an associate researcher. In 2021, he will complete his research training by obtaining an Habilitation to Supervise Research at the Université de la Réunion. Lastly, Scientific summary: CoBRA and MaharadjaProfessor COURET is leading a research protocol on a clinicobiological collection of stroke patients (CoBRA), with over 700 patients already included
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Selected PUBLICATIONS
Comparison of scales for the evaluation of aneurysmal subarachnoid haemorrhage: a retrospective cohort study.
Couret D, Boussen S, Cardoso D, Alonzo A, Madec S, Reyre A, Brunel H, Girard N, Graillon T, Dufour H, Bruder N, Boucekine M, Meilhac O, Simeone P, Velly L.Eur Radiol. 2024 Jun 5. doi: 10.1007/s00330-024-10814-4. Online ahead of print.PMID: 38836940
Metabolic disorders exacerbate the formation of glial scar after stroke.
Clain J, Couret D, Bringart M, Lecadieu A, Meilhac O, Lefebvre d'Hellencourt C, Diotel N.Eur J Neurosci. 2024 Jun;59(11):3009-3029. doi: 10.1111/ejn.16325. Epub 2024 Apr 4.PMID: 38576159
Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study.
Begue F, Chemello K, Veeren B, Lortat-Jacob B, Tran-Dinh A, Zappella N, Snauwaert A, Robert T, Rondeau P, Lagrange-Xelot M, Montravers P, Couret D, Tanaka S, Meilhac O.Int J Mol Sci. 2023 Feb 27;24(5):4605. doi: 10.3390/ijms24054605.PMID: 36902035 Free PMC article.
Lipoatrophic diabetes in familial partial lipodystrophy type 2: From insulin resistance to diabetes.
Treiber G, Guilleux A, Huynh K, Bonfanti O, Flaus-Furmaniuk A, Couret D, Mellet N, Bernard C, Le-Moullec N, Doray B, Jéru I, Maiza JC, Domun B, Cogne M, Meilhac O, Vigouroux C, Meikle PJ, Nobécourt E.Diabetes Metab. 2023 Mar;49(2):101409. doi: 10.1016/j.diabet.2022.101409. Epub 2022 Nov 15.PMID: 36400409
Distribution of Adiponectin Receptors in the Brain of Adult Mouse: Effect of a Single Dose of the Adiponectin Receptor Agonist, AdipoRON, on Ischemic Stroke.
Clain J, Couret D, Planesse C, Krejbich-Trotot P, Meilhac O, Lefebvre d'Hellencourt C, Viranaicken W, Diotel N.Brain Sci. 2022 May 23;12(5):680. doi: 10.3390/brainsci12050680.PMID: 35625066 Free PMC article.
Antioxidant Polyphenols of Antirhea borbonica Medicinal Plant and Caffeic Acid Reduce Cerebrovascular, Inflammatory and Metabolic Disorders Aggravated by High-Fat Diet-Induced Obesity in a Mouse Model of Stroke.
Taïlé J, Bringart M, Planesse C, Patché J, Rondeau P, Veeren B, Clerc P, Gauvin-Bialecki A, Bourane S, Meilhac O, Couret D, Gonthier MP.Antioxidants (Basel). 2022 Apr 27;11(5):858. doi: 10.3390/antiox11050858.PMID: 35624723 Free PMC article.
Author Correction: The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMIRNATY vaccine (Pfizer/BioNTech).
Andries J, Viranaicken W, Cordonin C, Herrscher C, Planesse C, Roquebert B, Lagrange-Xelot M, El-Kalamouni C, Meilhac O, Mavingui P, Couret D, Gadea G, Despres P.Sci Rep. 2022 Apr 20;12(1):6498. doi: 10.1038/s41598-022-10885-7.PMID: 35444227 Free PMC article. No abstract available.
The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMINARTY vaccine (Pfizer/BioNTech).
Andries J, Viranaicken W, Cordonin C, Herrscher C, Planesse C, Roquebert B, Lagrange-Xelot M, El-Kalamouni C, Meilhac O, Mavingui P, Couret D, Gadea G, Despres P.Sci Rep. 2022 Apr 9;12(1):5999. doi: 10.1038/s41598-022-10057-7.PMID: 35397679 Free PMC article.
Lack of Neuroprotective Effects of High-Density Lipoprotein Therapy in Stroke under Acute Hyperglycemic Conditions.
Couret D, Planesse C, Patche J, Diotel N, Nativel B, Bourane S, Meilhac O.Molecules. 2021 Oct 21;26(21):6365. doi: 10.3390/molecules26216365.PMID: 34770774 Free PMC article.
PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Inhibition in Hyperglycemic Mice Increases the Risk of Hemorrhagic Transformation of Ischemic Stroke.
Nativel B, Ramin-Mangata S, Couret D, Planesse C, Roche M, Gallo A, Meilhac O, Lambert G, Bourane S.Stroke. 2021 Aug;52(9):e545-e547. doi: 10.1161/STROKEAHA.121.035677. Epub 2021 Jul 28.PMID: 34315254
Cellular Mechanisms Participating in Brain Repair of Adult Zebrafish and Mammals after Injury.
Ghaddar B, Lübke L, Couret D, Rastegar S, Diotel N.Cells. 2021 Feb 14;10(2):391. doi: 10.3390/cells10020391.PMID: 33672842 Free PMC article. Review.
Altered high-density lipoprotein composition and functions during severe COVID-19.
Begue F, Tanaka S, Mouktadi Z, Rondeau P, Veeren B, Diotel N, Tran-Dinh A, Robert T, Vélia E, Mavingui P, Lagrange-Xélot M, Montravers P, Couret D, Meilhac O.Sci Rep. 2021 Jan 27;11(1):2291. doi: 10.1038/s41598-021-81638-1.PMID: 33504824 Free PMC article.
High-Density Lipoprotein Therapy in Stroke: Evaluation of Endothelial SR-BI-Dependent Neuroprotective Effects.
Tran-Dinh A, Levoye A, Couret D, Galle-Treger L, Moreau M, Delbosc S, Hoteit C, Montravers P, Amarenco P, Huby T, Meilhac O.Int J Mol Sci. 2020 Dec 24;22(1):106. doi: 10.3390/ijms22010106.PMID: 33374266 Free PMC article.
Changes in High-Density Lipoproteins Related to Outcomes in Patients with Acute Stroke.
Varela LM, Meseguer E, Lapergue B, Couret D, Amarenco P, Meilhac O.J Clin Med. 2020 Jul 17;9(7):2269. doi: 10.3390/jcm9072269.PMID: 32708891 Free PMC article.
Protective Effects of Antioxidant Polyphenols against Hyperglycemia-Mediated Alterations in Cerebral Endothelial Cells and a Mouse Stroke Model.
Arcambal A, Taïlé J, Couret D, Planesse C, Veeren B, Diotel N, Gauvin-Bialecki A, Meilhac O, Gonthier MP.Mol Nutr Food Res. 2020 Jul;64(13):e1900779. doi: 10.1002/mnfr.201900779. Epub 2020 Jun 16.PMID: 32447828
High-Density Lipoproteins Are Bug Scavengers.
Meilhac O, Tanaka S, Couret D.Biomolecules. 2020 Apr 12;10(4):598. doi: 10.3390/biom10040598.PMID: 32290632 Free PMC article. Review.
High-density lipoproteins during sepsis: from bench to bedside.
Tanaka S, Couret D, Tran-Dinh A, Duranteau J, Montravers P, Schwendeman A, Meilhac O.Crit Care. 2020 Apr 7;24(1):134. doi: 10.1186/s13054-020-02860-3.PMID: 32264946 Free PMC article. Review.
Reconstituted High-density Lipoprotein Therapy Improves Survival in Mouse Models of Sepsis.
Tanaka S, Genève C, Zappella N, Yong-Sang J, Planesse C, Louedec L, Viranaïcken W, Bringart M, Montravers P, Denamur E, Duranteau J, Couret D, Meilhac O.Anesthesiology. 2020 Apr;132(4):825-838. doi: 10.1097/ALN.0000000000003155.PMID: 32101976 Free article.
Expression of adiponectin receptors in the brain of adult zebrafish and mouse: Links with neurogenic niches and brain repair.
Rastegar S, Parimisetty A, Cassam Sulliman N, Narra SS, Weber S, Rastegar M, Viranaicken W, Couret D, Planesse C, Strähle U, Meilhac O, Lefebvre d'Hellencourt C, Diotel N.J Comp Neurol. 2019 Oct 1;527(14):2317-2333. doi: 10.1002/cne.24669. Epub 2019 Mar 29.PMID: 30843204
Couret D, Boussen S, Cardoso D, Alonzo A, Madec S, Reyre A, Brunel H, Girard N, Graillon T, Dufour H, Bruder N, Boucekine M, Meilhac O, Simeone P, Velly L.Eur Radiol. 2024 Jun 5. doi: 10.1007/s00330-024-10814-4. Online ahead of print.PMID: 38836940
Metabolic disorders exacerbate the formation of glial scar after stroke.
Clain J, Couret D, Bringart M, Lecadieu A, Meilhac O, Lefebvre d'Hellencourt C, Diotel N.Eur J Neurosci. 2024 Jun;59(11):3009-3029. doi: 10.1111/ejn.16325. Epub 2024 Apr 4.PMID: 38576159
Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study.
Begue F, Chemello K, Veeren B, Lortat-Jacob B, Tran-Dinh A, Zappella N, Snauwaert A, Robert T, Rondeau P, Lagrange-Xelot M, Montravers P, Couret D, Tanaka S, Meilhac O.Int J Mol Sci. 2023 Feb 27;24(5):4605. doi: 10.3390/ijms24054605.PMID: 36902035 Free PMC article.
Lipoatrophic diabetes in familial partial lipodystrophy type 2: From insulin resistance to diabetes.
Treiber G, Guilleux A, Huynh K, Bonfanti O, Flaus-Furmaniuk A, Couret D, Mellet N, Bernard C, Le-Moullec N, Doray B, Jéru I, Maiza JC, Domun B, Cogne M, Meilhac O, Vigouroux C, Meikle PJ, Nobécourt E.Diabetes Metab. 2023 Mar;49(2):101409. doi: 10.1016/j.diabet.2022.101409. Epub 2022 Nov 15.PMID: 36400409
Distribution of Adiponectin Receptors in the Brain of Adult Mouse: Effect of a Single Dose of the Adiponectin Receptor Agonist, AdipoRON, on Ischemic Stroke.
Clain J, Couret D, Planesse C, Krejbich-Trotot P, Meilhac O, Lefebvre d'Hellencourt C, Viranaicken W, Diotel N.Brain Sci. 2022 May 23;12(5):680. doi: 10.3390/brainsci12050680.PMID: 35625066 Free PMC article.
Antioxidant Polyphenols of Antirhea borbonica Medicinal Plant and Caffeic Acid Reduce Cerebrovascular, Inflammatory and Metabolic Disorders Aggravated by High-Fat Diet-Induced Obesity in a Mouse Model of Stroke.
Taïlé J, Bringart M, Planesse C, Patché J, Rondeau P, Veeren B, Clerc P, Gauvin-Bialecki A, Bourane S, Meilhac O, Couret D, Gonthier MP.Antioxidants (Basel). 2022 Apr 27;11(5):858. doi: 10.3390/antiox11050858.PMID: 35624723 Free PMC article.
Author Correction: The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMIRNATY vaccine (Pfizer/BioNTech).
Andries J, Viranaicken W, Cordonin C, Herrscher C, Planesse C, Roquebert B, Lagrange-Xelot M, El-Kalamouni C, Meilhac O, Mavingui P, Couret D, Gadea G, Despres P.Sci Rep. 2022 Apr 20;12(1):6498. doi: 10.1038/s41598-022-10885-7.PMID: 35444227 Free PMC article. No abstract available.
The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMINARTY vaccine (Pfizer/BioNTech).
Andries J, Viranaicken W, Cordonin C, Herrscher C, Planesse C, Roquebert B, Lagrange-Xelot M, El-Kalamouni C, Meilhac O, Mavingui P, Couret D, Gadea G, Despres P.Sci Rep. 2022 Apr 9;12(1):5999. doi: 10.1038/s41598-022-10057-7.PMID: 35397679 Free PMC article.
Lack of Neuroprotective Effects of High-Density Lipoprotein Therapy in Stroke under Acute Hyperglycemic Conditions.
Couret D, Planesse C, Patche J, Diotel N, Nativel B, Bourane S, Meilhac O.Molecules. 2021 Oct 21;26(21):6365. doi: 10.3390/molecules26216365.PMID: 34770774 Free PMC article.
PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Inhibition in Hyperglycemic Mice Increases the Risk of Hemorrhagic Transformation of Ischemic Stroke.
Nativel B, Ramin-Mangata S, Couret D, Planesse C, Roche M, Gallo A, Meilhac O, Lambert G, Bourane S.Stroke. 2021 Aug;52(9):e545-e547. doi: 10.1161/STROKEAHA.121.035677. Epub 2021 Jul 28.PMID: 34315254
Cellular Mechanisms Participating in Brain Repair of Adult Zebrafish and Mammals after Injury.
Ghaddar B, Lübke L, Couret D, Rastegar S, Diotel N.Cells. 2021 Feb 14;10(2):391. doi: 10.3390/cells10020391.PMID: 33672842 Free PMC article. Review.
Altered high-density lipoprotein composition and functions during severe COVID-19.
Begue F, Tanaka S, Mouktadi Z, Rondeau P, Veeren B, Diotel N, Tran-Dinh A, Robert T, Vélia E, Mavingui P, Lagrange-Xélot M, Montravers P, Couret D, Meilhac O.Sci Rep. 2021 Jan 27;11(1):2291. doi: 10.1038/s41598-021-81638-1.PMID: 33504824 Free PMC article.
High-Density Lipoprotein Therapy in Stroke: Evaluation of Endothelial SR-BI-Dependent Neuroprotective Effects.
Tran-Dinh A, Levoye A, Couret D, Galle-Treger L, Moreau M, Delbosc S, Hoteit C, Montravers P, Amarenco P, Huby T, Meilhac O.Int J Mol Sci. 2020 Dec 24;22(1):106. doi: 10.3390/ijms22010106.PMID: 33374266 Free PMC article.
Changes in High-Density Lipoproteins Related to Outcomes in Patients with Acute Stroke.
Varela LM, Meseguer E, Lapergue B, Couret D, Amarenco P, Meilhac O.J Clin Med. 2020 Jul 17;9(7):2269. doi: 10.3390/jcm9072269.PMID: 32708891 Free PMC article.
Protective Effects of Antioxidant Polyphenols against Hyperglycemia-Mediated Alterations in Cerebral Endothelial Cells and a Mouse Stroke Model.
Arcambal A, Taïlé J, Couret D, Planesse C, Veeren B, Diotel N, Gauvin-Bialecki A, Meilhac O, Gonthier MP.Mol Nutr Food Res. 2020 Jul;64(13):e1900779. doi: 10.1002/mnfr.201900779. Epub 2020 Jun 16.PMID: 32447828
High-Density Lipoproteins Are Bug Scavengers.
Meilhac O, Tanaka S, Couret D.Biomolecules. 2020 Apr 12;10(4):598. doi: 10.3390/biom10040598.PMID: 32290632 Free PMC article. Review.
High-density lipoproteins during sepsis: from bench to bedside.
Tanaka S, Couret D, Tran-Dinh A, Duranteau J, Montravers P, Schwendeman A, Meilhac O.Crit Care. 2020 Apr 7;24(1):134. doi: 10.1186/s13054-020-02860-3.PMID: 32264946 Free PMC article. Review.
Reconstituted High-density Lipoprotein Therapy Improves Survival in Mouse Models of Sepsis.
Tanaka S, Genève C, Zappella N, Yong-Sang J, Planesse C, Louedec L, Viranaïcken W, Bringart M, Montravers P, Denamur E, Duranteau J, Couret D, Meilhac O.Anesthesiology. 2020 Apr;132(4):825-838. doi: 10.1097/ALN.0000000000003155.PMID: 32101976 Free article.
Expression of adiponectin receptors in the brain of adult zebrafish and mouse: Links with neurogenic niches and brain repair.
Rastegar S, Parimisetty A, Cassam Sulliman N, Narra SS, Weber S, Rastegar M, Viranaicken W, Couret D, Planesse C, Strähle U, Meilhac O, Lefebvre d'Hellencourt C, Diotel N.J Comp Neurol. 2019 Oct 1;527(14):2317-2333. doi: 10.1002/cne.24669. Epub 2019 Mar 29.PMID: 30843204