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Marie-Paule Gonthier holds a PhD degree in Human Nutrition from the Faculty of Medicine of Clermont-Ferrand, France, in 2003. Her work consisted on exploring the role of gut microbiota on the metabolic fate and bioavailability of dietary polyphenols in humans. After a post-doctoral period in the Endocannabinoid Research Group led by Prof. Vincenzo Di Marzo (National Research Center of Naples, Italy), she was hired assistant professor for 7 years at the University of La Réunion, France. In 2013, she became full professor at the Faculty of Health of the University of La Réunion. There, she teaches biochemistry and nutrition, and supervises students from the 3rd year of Medicine school. Since 2015, she’s a member of DéTROI group and contributes to explore the mechanisms involved in the dysregulation of metabolic and inflammatory functions of different cellular types (adipocytes, endothelial cells, Schwann cells) in conditions related to obesity, type 2 diabetes and neurovascular disorders (stroke, peripheral neuropathy). Moreover, her work aims to evaluate the protective effects of plant polyphenols as new nutritional and pharmacological strategies helping to reduce metabolic and neurovascular complications during obesity/type 2 diabetes. She currently investigates the links between oral/gut microbiota dysbiosis, inflammation and metabolic disorders during obesity, and evaluates plant polyphenol benefits to counteract microbiota dysbiosis impact on metabolic health. This work is based on in vitro cellular models, preclinical animal models and clinical trials conducted with clinicians from La Réunion University Hospital.
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Scientific summary
Key words: obesity, diabetes, microbiota, nutrition, polyphenols
selected PUBLICATIONS
Adipokines and Bacterial Metabolites: A Pivotal Molecular Bridge Linking Obesity and Gut Microbiota Dysbiosis to Target.
Turpin T, Thouvenot K, Gonthier MP.Biomolecules. 2023 Nov 23;13(12):1692. doi: 10.3390/biom13121692.PMID: 38136564 Free PMC article. Review.
Familial partial lipodystrophy type 2 and obesity, two adipose tissue pathologies with different inflammatory profiles.
Treiber G, Gonthier MP, Guilleux A, Medjane S, Bonfanti O, Cogne M, Meilhac O, Nobecourt E.Diabetol Metab Syndr. 2023 Apr 21;15(1):77. doi: 10.1186/s13098-023-01055-4.PMID: 37081489 Free PMC article.
Antioxidant Polyphenols of Antirhea borbonica Medicinal Plant and Caffeic Acid Reduce Cerebrovascular, Inflammatory and Metabolic Disorders Aggravated by High-Fat Diet-Induced Obesity in a Mouse Model of Stroke.
Taïlé J, Bringart M, Planesse C, Patché J, Rondeau P, Veeren B, Clerc P, Gauvin-Bialecki A, Bourane S, Meilhac O, Couret D, Gonthier MP.Antioxidants (Basel). 2022 Apr 27;11(5):858. doi: 10.3390/antiox11050858.PMID: 35624723 Free PMC article.
ApoA-I Nanoparticles as Curcumin Carriers for Cerebral Endothelial Cells: Improved Cytoprotective Effects against Methylglyoxal.
Narra SS, Rosanaly S, Rondeau P, Patche J, Veeren B, Gonthier MP, Viranaicken W, Diotel N, Ravanan P, Hellencourt CL, Meilhac O.Pharmaceuticals (Basel). 2022 Mar 13;15(3):347. doi: 10.3390/ph15030347.PMID: 35337146 Free PMC article.
Links between Insulin Resistance and Periodontal Bacteria: Insights on Molecular Players and Therapeutic Potential of Polyphenols.
Thouvenot K, Turpin T, Taïlé J, Clément K, Meilhac O, Gonthier MP.Biomolecules. 2022 Feb 28;12(3):378. doi: 10.3390/biom12030378.PMID: 35327570 Free PMC article. Review.
Antioxidant and Cytoprotective Properties of Polyphenol-Rich Extracts from Antirhea borbonica and Doratoxylon apetalum against Atherogenic Lipids in Human Endothelial Cells.
Bonneville J, Rondeau P, Veeren B, Faccini J, Gonthier MP, Meilhac O, Vindis C.Antioxidants (Basel). 2021 Dec 24;11(1):34. doi: 10.3390/antiox11010034.PMID: 35052538 Free PMC article.
The aim of this study was to evaluate the vascular antioxidant and cytoprotective effects of polyphenol-rich extracts from two medicinal plants from the Reunion Island: Antirhea borbonica (A. borbonica), Doratoxylon apetalum (D. apetalum). ...All together, these results sh …
Phenolic Profile of Herbal Infusion and Polyphenol-Rich Extract from Leaves of the Medicinal Plant Antirhea borbonica: Toxicity Assay Determination in Zebrafish Embryos and Larvae.
Veeren B, Ghaddar B, Bringart M, Khazaal S, Gonthier MP, Meilhac O, Diotel N, Bascands JL.Molecules. 2020 Sep 29;25(19):4482. doi: 10.3390/molecules25194482.PMID: 33003608 Free PMC article.
Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease.
Ruskovska T, Massaro M, Carluccio MA, Arola-Arnal A, Muguerza B, Vanden Berghe W, Declerck K, Bravo FI, Calabriso N, Combet E, Gibney ER, Gomes A, Gonthier MP, Kistanova E, Krga I, Mena P, Morand C, Nunes Dos Santos C, de Pascual-Teresa S, Rodriguez-Mateos A, Scoditti E, Suárez M, Milenkovic D.Food Funct. 2020 Jun 24;11(6):5040-5064. doi: 10.1039/d0fo00701c.PMID: 32537624 Free article.
Protective Effects of Antioxidant Polyphenols against Hyperglycemia-Mediated Alterations in Cerebral Endothelial Cells and a Mouse Stroke Model.
Arcambal A, Taïlé J, Couret D, Planesse C, Veeren B, Diotel N, Gauvin-Bialecki A, Meilhac O, Gonthier MP.Mol Nutr Food Res. 2020 Jul;64(13):e1900779. doi: 10.1002/mnfr.201900779. Epub 2020 Jun 16.PMID: 32447828
Hyperglycemia modulates redox, inflammatory and vasoactive markers through specific signaling pathways in cerebral endothelial cells: Insights on insulin protective action.
Arcambal A, Taïlé J, Rondeau P, Viranaïcken W, Meilhac O, Gonthier MP.Free Radic Biol Med. 2019 Jan;130:59-70. doi: 10.1016/j.freeradbiomed.2018.10.430. Epub 2018 Oct 23.PMID: 30359759
Turpin T, Thouvenot K, Gonthier MP.Biomolecules. 2023 Nov 23;13(12):1692. doi: 10.3390/biom13121692.PMID: 38136564 Free PMC article. Review.
Familial partial lipodystrophy type 2 and obesity, two adipose tissue pathologies with different inflammatory profiles.
Treiber G, Gonthier MP, Guilleux A, Medjane S, Bonfanti O, Cogne M, Meilhac O, Nobecourt E.Diabetol Metab Syndr. 2023 Apr 21;15(1):77. doi: 10.1186/s13098-023-01055-4.PMID: 37081489 Free PMC article.
Antioxidant Polyphenols of Antirhea borbonica Medicinal Plant and Caffeic Acid Reduce Cerebrovascular, Inflammatory and Metabolic Disorders Aggravated by High-Fat Diet-Induced Obesity in a Mouse Model of Stroke.
Taïlé J, Bringart M, Planesse C, Patché J, Rondeau P, Veeren B, Clerc P, Gauvin-Bialecki A, Bourane S, Meilhac O, Couret D, Gonthier MP.Antioxidants (Basel). 2022 Apr 27;11(5):858. doi: 10.3390/antiox11050858.PMID: 35624723 Free PMC article.
ApoA-I Nanoparticles as Curcumin Carriers for Cerebral Endothelial Cells: Improved Cytoprotective Effects against Methylglyoxal.
Narra SS, Rosanaly S, Rondeau P, Patche J, Veeren B, Gonthier MP, Viranaicken W, Diotel N, Ravanan P, Hellencourt CL, Meilhac O.Pharmaceuticals (Basel). 2022 Mar 13;15(3):347. doi: 10.3390/ph15030347.PMID: 35337146 Free PMC article.
Links between Insulin Resistance and Periodontal Bacteria: Insights on Molecular Players and Therapeutic Potential of Polyphenols.
Thouvenot K, Turpin T, Taïlé J, Clément K, Meilhac O, Gonthier MP.Biomolecules. 2022 Feb 28;12(3):378. doi: 10.3390/biom12030378.PMID: 35327570 Free PMC article. Review.
Antioxidant and Cytoprotective Properties of Polyphenol-Rich Extracts from Antirhea borbonica and Doratoxylon apetalum against Atherogenic Lipids in Human Endothelial Cells.
Bonneville J, Rondeau P, Veeren B, Faccini J, Gonthier MP, Meilhac O, Vindis C.Antioxidants (Basel). 2021 Dec 24;11(1):34. doi: 10.3390/antiox11010034.PMID: 35052538 Free PMC article.
The aim of this study was to evaluate the vascular antioxidant and cytoprotective effects of polyphenol-rich extracts from two medicinal plants from the Reunion Island: Antirhea borbonica (A. borbonica), Doratoxylon apetalum (D. apetalum). ...All together, these results sh …
Phenolic Profile of Herbal Infusion and Polyphenol-Rich Extract from Leaves of the Medicinal Plant Antirhea borbonica: Toxicity Assay Determination in Zebrafish Embryos and Larvae.
Veeren B, Ghaddar B, Bringart M, Khazaal S, Gonthier MP, Meilhac O, Diotel N, Bascands JL.Molecules. 2020 Sep 29;25(19):4482. doi: 10.3390/molecules25194482.PMID: 33003608 Free PMC article.
Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease.
Ruskovska T, Massaro M, Carluccio MA, Arola-Arnal A, Muguerza B, Vanden Berghe W, Declerck K, Bravo FI, Calabriso N, Combet E, Gibney ER, Gomes A, Gonthier MP, Kistanova E, Krga I, Mena P, Morand C, Nunes Dos Santos C, de Pascual-Teresa S, Rodriguez-Mateos A, Scoditti E, Suárez M, Milenkovic D.Food Funct. 2020 Jun 24;11(6):5040-5064. doi: 10.1039/d0fo00701c.PMID: 32537624 Free article.
Protective Effects of Antioxidant Polyphenols against Hyperglycemia-Mediated Alterations in Cerebral Endothelial Cells and a Mouse Stroke Model.
Arcambal A, Taïlé J, Couret D, Planesse C, Veeren B, Diotel N, Gauvin-Bialecki A, Meilhac O, Gonthier MP.Mol Nutr Food Res. 2020 Jul;64(13):e1900779. doi: 10.1002/mnfr.201900779. Epub 2020 Jun 16.PMID: 32447828
Hyperglycemia modulates redox, inflammatory and vasoactive markers through specific signaling pathways in cerebral endothelial cells: Insights on insulin protective action.
Arcambal A, Taïlé J, Rondeau P, Viranaïcken W, Meilhac O, Gonthier MP.Free Radic Biol Med. 2019 Jan;130:59-70. doi: 10.1016/j.freeradbiomed.2018.10.430. Epub 2018 Oct 23.PMID: 30359759