Wildriss Viranaïcken
 Maitre de ConférenceS
​
Education
    2018 HDR, University of Reunion Island, France.
    2005 PhD, Université Pierre et Marie Curie, Paris, France, Protein biochemistry.
    2002 Master, Université Pierre et Marie Curie, Paris, France, Structure Function and engineering of proteins, functional integration of proteins.
Professional Experience
    2019-          Assistant professor in biochemestry and molecular biology
    2015-2019 Research engineer, University of Reunion Island, France, UMR PIMIT, UM134
    2012-2015 Design engineer, University of Reunion Island, France, EA4517
    2011-2012 Research Engineer, University of Reunion Island, France, EA4517
    2010-2011 Temporary Assistant Professor, University of Reunion Island, EA4516 (GEICO) and EA4517 (GRI), UFR Santé.
  2006-2009 Post-doc University of Montreal, Department of Biochemistry, team of Prof. Luc Desgroseillers.
Expertise and research areas
  1. Molecular interactions between hosts and microbes in the context of vascular diseases.
  2. Immunopathology of vascular diseases.
  3. Development of molecular biology tools for the study of vascular diseases and biotechnologies for therapy.
Teaching fields
  1. Biochemistry
  2. Molecular and cell biology
  3. Applied biotechnology

Scientific summary

Immunometabolism of Pathological Processes: Regulations, Diagnostics, and Therapies

Scientific Production 

  • https://orcid.org/0000-0002-0915-8635
  • https://www.researchgate.net/profile/Wildriss-Viranaicken
  • https://pubmed.ncbi.nlm.nih.gov/?term=viranaicken+wildriss&sort=date
  • https://re.linkedin.com/in/wildriss-viranaicken-b0b06993 ​

TECHNICS AND METHODS

Cellular Biochemistry and Molecular Biology Approaches

selected PUBLICATIONS

  1. Exosome-Mediated Antigen Delivery: Unveiling Novel Strategies in Viral Infection Control and Vaccine Design.El Safadi D, Mokhtari A, Krejbich M, Lagrave A, Hirigoyen U, Lebeau G, Viranaicken W, Krejbich-Trotot P.Vaccines (Basel). 2024 Mar 7;12(3):280. doi: 10.3390/vaccines12030280.PMID: 38543914 Free PMC article. Review.
  2. Cell cycle and mitosis progression during ZIKA virus infection: The viral non-structural protein NS5 as a master regulator of the APC/cyclosome?Lebeau G, Hoareau M, Rivière S, El Safadi D, Da Silva CR, Krejbich-Trotot P, Viranaicken W.Biochimie. 2024 Jun;221:75-80. doi: 10.1016/j.biochi.2024.01.016. Epub 2024 Feb 1.PMID: 38307244
  3. The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression.El Safadi D, Lebeau G, Turpin J, Lefebvre d'Hellencourt C, Diotel N, Viranaicken W, Krejbich-Trotot P.Viruses. 2023 Dec 22;16(1):24. doi: 10.3390/v16010024.PMID: 38257725 Free PMC article.
  4. The Influence of Metabolism on Immune Response: A Journey to Understand Immunometabolism in the Context of Viral Infection.El Safadi D, Paulo-Ramos A, Hoareau M, Roche M, Krejbich-Trotot P, Viranaicken W, Lebeau G.Viruses. 2023 Dec 9;15(12):2399. doi: 10.3390/v15122399.PMID: 38140640 Free PMC article. Review.
  5. Zika virus restriction of host antioxidant response is mediated by intracellular NS1 and reveals its ability to upregulate Bach1 expression.Lebeau G, El Safadi D, Hoarau M, Meilhac O, Krejbich-Trotot P, Viranaicken W.Biochem Biophys Res Commun. 2024 Jan 1;690:149312. doi: 10.1016/j.bbrc.2023.149312. Epub 2023 Nov 23.PMID: 38016247
  6. Extracellular Vesicles Are Conveyors of the NS1 Toxin during Dengue Virus and Zika Virus Infection.Safadi DE, Lebeau G, Lagrave A, Mélade J, Grondin L, Rosanaly S, Begue F, Hoareau M, Veeren B, Roche M, Hoarau JJ, Meilhac O, Mavingui P, Desprès P, Viranaïcken W, Krejbich-Trotot P.Viruses. 2023 Jan 27;15(2):364. doi: 10.3390/v15020364.PMID: 36851578 Free PMC article.
  7. The Efficient Antiviral Response of A549 Cells Is Enhanced When Mitochondrial Respiration Is Promoted.Lebeau G, El Safadi D, Paulo-Ramos A, Hoareau M, Desprès P, Krejbich-Trotot P, Chouchou F, Roche M, Viranaicken W.Pathogens. 2022 Oct 11;11(10):1168. doi: 10.3390/pathogens11101168.PMID: 36297225 Free PMC article.
  8. Distribution of Adiponectin Receptors in the Brain of Adult Mouse: Effect of a Single Dose of the Adiponectin Receptor Agonist, AdipoRON, on Ischemic Stroke.
  9. Clain J, Couret D, Planesse C, Krejbich-Trotot P, Meilhac O, Lefebvre d'Hellencourt C, Viranaicken W, Diotel N.Brain Sci. 2022 May 23;12(5):680. doi: 10.3390/brainsci12050680.PMID: 35625066 Free PMC article.
  10. Author Correction: The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMIRNATY vaccine (Pfizer/BioNTech).
  11. Andries J, Viranaicken W, Cordonin C, Herrscher C, Planesse C, Roquebert B, Lagrange-Xelot M, El-Kalamouni C, Meilhac O, Mavingui P, Couret D, Gadea G, Despres P.Sci Rep. 2022 Apr 20;12(1):6498. doi: 10.1038/s41598-022-10885-7.PMID: 35444227 Free PMC article. No abstract available.
  12. The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMINARTY vaccine (Pfizer/BioNTech).
  13. Andries J, Viranaicken W, Cordonin C, Herrscher C, Planesse C, Roquebert B, Lagrange-Xelot M, El-Kalamouni C, Meilhac O, Mavingui P, Couret D, Gadea G, Despres P.Sci Rep. 2022 Apr 9;12(1):5999. doi: 10.1038/s41598-022-10057-7.PMID: 35397679 Free PMC article.
  14. ApoA-I Nanoparticles as Curcumin Carriers for Cerebral Endothelial Cells: Improved Cytoprotective Effects against Methylglyoxal.
  15. Narra SS, Rosanaly S, Rondeau P, Patche J, Veeren B, Gonthier MP, Viranaicken W, Diotel N, Ravanan P, Hellencourt CL, Meilhac O.Pharmaceuticals (Basel). 2022 Mar 13;15(3):347. doi: 10.3390/ph15030347.PMID: 35337146 Free PMC article.
  16. Zika E Glycan Loop Region and Guillain-Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development.
  17. Lebeau G, Frumence E, Turpin J, Begue F, Hoarau JJ, Gadea G, Krejbich-Trotot P, Desprès P, Viranaicken W.Vaccines (Basel). 2021 Mar 19;9(3):283. doi: 10.3390/vaccines9030283.PMID: 33808706 Free PMC article.
  18. Protective Effects of Medicinal Plant Decoctions on Macrophages in the Context of Atherosclerosis.
  19. Checkouri E, Ramin-Mangata S, Diotel N, Viranaicken W, Marodon C, Reignier F, Robert-Da Silva C, Meilhac O.Nutrients. 2021 Jan 19;13(1):280. doi: 10.3390/nu13010280.PMID: 33478034 Free PMC article.
  20. The Geraniin-Rich Extract from Reunion Island Endemic Medicinal Plant Phyllanthus phillyreifolius Inhibits Zika and Dengue Virus Infection at Non-Toxic Effect Doses in Zebrafish.
  21. Haddad JG, Grauzdytė D, Koishi AC, Viranaicken W, Venskutonis PR, Nunes Duarte Dos Santos C, Desprès P, Diotel N, El Kalamouni C.Molecules. 2020 May 15;25(10):2316. doi: 10.3390/molecules25102316.PMID: 32429073 Free PMC article.
  22. Improvement of immunodetection of the transcription factor C/EBP homologous protein by western blot.
  23. Turpin J, Frumence E, El Safadi D, Meilhac O, Krejbich-Trotot P, Viranaïcken W.Anal Biochem. 2020 Jul 15;601:113775. doi: 10.1016/j.ab.2020.113775. Epub 2020 May 13.PMID: 32416096
  24. Reconstituted High-density Lipoprotein Therapy Improves Survival in Mouse Models of Sepsis. Tanaka S, Genève C, Zappella N, Yong-Sang J, Planesse C, Louedec L, Viranaïcken W, Bringart M, Montravers P, Denamur E, Duranteau J, Couret D, Meilhac O. Anesthesiology. 2020 Feb 20.  doi:10.1097/ALN.0000000000003155.
  25. The Envelope Residues E152/156/158 of Zika Virus Influence the Early Stages of Virus Infection in Human Cells. Bos S, Viranaicken W, Frumence E, Li G, Desprès P, Zhao RY, Gadea G. Cells. 2019 Nov 15;8(11). pii: E1444. doi: 10.3390/cells8111444.
  26. The ZIKA Virus Delays Cell Death Through the Anti-Apoptotic Bcl-2 Family Proteins. Turpin J, Frumence E, Desprès P, Viranaicken W*, Krejbich-Trotot P*. Cells. 2019 Oct 29;8(11). pii: E1338. doi: 10.3390/cells8111338. *co-senior
  27. CD93 is a cell surface lectin receptor involved in the control of the inflammatory response stimulated by exogenous DNA. Nativel B, Ramin-Mangata S, Mevizou R, Figuester A, Andries J, Iwema T, Ikewaki N, Gasque P*, Viranaïcken W*. Immunology. 2019 Oct;158(2):85-93. doi: 10.1111/imm.13100. Epub 2019 Jul 23. *co-senior
  28. A GFP Reporter MR766-Based Flow Cytometry Neutralization Test for Rapid Detection of Zika Virus-Neutralizing Antibodies in Serum Specimens. Frumence E, Viranaicken W, Gadea G, Desprès P. Vaccines (Basel). 2019 Jul 16;7(3). pii: E66. doi: 10.3390/vaccines7030066.
  29. A Chimeric Zika Virus between Viral Strains MR766 and BeH819015 Highlights a Role for E-glycan Loop in Antibody-mediated Virus Neutralization. Frumence E, Viranaicken W, Bos S, Alvarez-Martinez MT, Roche M, Arnaud JD, Gadea G, Desprès P. Vaccines (Basel). 2019 Jun 24;7(2). pii: E55. doi: 10.3390/vaccines7020055.
  30. Doratoxylon apetalum, an Indigenous Medicinal Plant from Mascarene Islands, Is a Potent Inhibitor of Zika and Dengue Virus Infection in Human Cells. Haddad JG, Koishi AC, Gaudry A, Nunes Duarte Dos Santos C, Viranaicken W, Desprès P, El Kalamouni C. Int J Mol Sci. 2019 May 14;20(10). pii: E2382. doi: 10.3390/ijms20102382.
  31. Expression of adiponectin receptors in the brain of adult zebrafish and mouse: Links with neurogenic niches and brain repair.Rastegar S, Parimisetty A, Cassam Sulliman N, Narra SS, Weber S, Rastegar M, Viranaicken W, Couret D, Planesse C, Strähle U, Meilhac O, Lefebvre d'Hellencourt C, Diotel N. J Comp Neurol. 2019 Oct 1;527(14):2317-2333. doi: 10.1002/cne.24669. Epub 2019 Mar 29.
  32. Advanced glycation end-products disrupt human endothelial cells redox homeostasis: new insights into reactive oxygen species production. Dobi A, Bravo SB, Veeren B, Paradela-Dobarro B, Álvarez E, Meilhac O, Viranaicken W, Baret P, Devin A, Rondeau P. Free Radic Res. 2019 Mar 1:1-20. doi: 10.1080/10715762.2018.1529866.
  33.  Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus. El Kalamouni C, Frumence E, Bos S, Turpin J, Nativel B, Harrabi W, Wilkinson DA, Meilhac O, Gadea G, Desprès P, Krejbich-Trotot* P, Viranaïcken W*. Viruses. 2018 Dec 20;11(1). pii: E2. doi: 10.3390/v11010002. *co-senior
  34.  Protective effects of Phyllanthus phillyreifolius extracts against hydrogen peroxide induced oxidative stress in HEK293 cells. Grauzdytė D, Pukalskas A, Viranaicken W, El Kalamouni C, Venskutonis PR. PLoS One. 2018 Nov 16;13(11):e0207672. doi: 10.1371/journal.pone.0207672.
  35.  Hyperglycemia modulates redox, inflammatory and vasoactive markers through specific signaling pathways in cerebral endothelial cells: Insights on insulin protective action. Arcambal A, Taïlé J, Rondeau P, Viranaïcken W, Meilhac O, Gonthier MP. Free Radic Biol Med. 2018 Oct 23;130:59-70. doi: 10.1016/j.freeradbiomed.2018.10.430.
  36.  Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface. Clain E, Sinigaglia L, Koishi AC, Gorgette O, Gadea G, Viranaicken W, Krejbich-Trotot P, Mavingui P, Desprès P, Nunes Duarte Dos Santos C, Guiraud P, Jouvenet N, El Kalamouni C. Sci Rep. 2018 Jul 18;8(1):10856. doi: 10.1038/s41598-018-29183-2
  37.  In vitro comparison of three common essential oils mosquito repellents as inhibitors of the Ross River virus. Ralambondrainy M, Belarbi E, Viranaicken W, Baranauskienė R, Venskutonis PR, Desprès P, Roques P, El Kalamouni C, Sélambarom J. PLoS One. 2018 May 17;13(5):e0196757. doi: 10.1371/journal.pone.0196757.
  38.  The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells. Gaudry A, Bos S, Viranaicken W, Roche M, Krejbich-Trotot P, Gadea G, Desprès P, El-Kalamouni C. Int J Mol Sci. 2018 Apr 5;19(4). pii: E1093. doi: 10.3390/ijms19041093.
  39.  The structural proteins of epidemic and historical strains of Zika virus differ in their ability to initiate viral infection in human host cells. Bos S, Viranaicken W, Turpin J, El-Kalamouni C, Roche M, Krejbich-Trotot P, Desprès P, Gadea G. Virology. 2018 Mar;516:265-273. doi: 10.1016/j.virol.2017.12.003. Epub 2018 Feb 1.
  40.  Recombinant Zika NS1 Protein Secreted from Vero Cells Is Efficient for Inducing Production of Immune Serum Directed against NS1 Dimer. Viranaicken W, Ndebo A, Bos S, Souque P, Gadea G, El-Kalamouni C, Krejbich-Trotot P, Charneau P, Desprès P, Roche M. Int J Mol Sci. 2017 Dec 23;19(1). pii: E38. doi: 10.3390/ijms19010038.
  41.  Porphyromonas gingivalis lipopolysaccharides act exclusively through TLR4 with a resilience between mouse and human. Nativel B, Couret D, Giraud P, Meilhac O, d'Hellencourt CL, Viranaïcken W*, Da Silva CR*. Sci Rep. 2017 Nov 17;7(1):15789. doi: 10.1038/s41598-017-16190-y. *co-senior
  42.  ClearColi BL21 (DE3)-based expression of Zika virus antigens illustrates a rapid method of antibody production against emerging pathogens. Viranaicken W*, Nativel B, Krejbich-Trotot P, Harrabi W, Bos S, El Kalamouni C, Roche M, Gadea G, Desprès P. Biochimie. 2017 Nov; 142:179-182. doi: 10.1016/j.biochi.2017.09.011. Epub 2017 Sep 20. *corresponding author
  43.  The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1. Beaujois R, Ottoni E, Zhang X, Gagnon C, HSine S, Mollet S, Viranaicken W, DesGroseillers L. BMC Cell Biol. 2017 Jul 14;18(1):25. doi: 10.1186/s12860-017-0142-z.
  44.  Soluble expression of disulfide-bonded C-type lectin like domain of human CD93 in the cytoplasm of Escherichia coli. Nativel B, Figuester A, Andries J, Planesse C, Couprie J, Gasque P, Viranaicken W*, Iwema T*. J Immunol Methods. 2016 Dec; 439:67-73. doi: 10.1016/j.jim.2016.10.003. *co-senior
  45.  The growth of arthralgic Ross River virus is restricted in human monocytic cells. Krejbich-Trotot P, Belarbi E, Ralambondrainy M, El-Kalamouni C, Viranaicken W, Roques P, Desprès P, Gadea G. Virus Res. 2016 Oct 2;225:64-68. doi: 10.1016/j.virusres.2016.09.007.